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Biochemistry II

Syllabus
Schedule: winter semester - summer semester
Topics
The list of structures for the test of Biochemistry
The lectures' review questions

Information about the practical training:
- use your own laboratory coat (without it you will not be allowed to participate and you will be considered absent),
- come to practical classes with the corresponding protocol (printed out in advance) and prepared for the lesson according to that protocol (see below)

Credit conditions:
winter semester
- participation in seminars and laboratory practices (2 absences allowed)
- presentation of laboratory reports
- participation in the written tests
summer semester
- participation in seminars and laboratory practices (2 absences allowed)
- presentation of laboratory reports
- participation in the written tests
- laboratory analysis of uknown sample of serum or urine (independent task)

2^nd year - winter semester

Materials:

Lectures	Seminars	Protocols for practical trainings
Bioenergetics Biosynthesis and degradation of proteins Cholesterol and its transport Detoxification of endogenous and exogenous compounds Electron transport chain, oxidative phosphorylation & mitochondrial transport systems Fatty acid metabolism Glycolysis and Gluconeogenesis Glycoproteins and mucins Immunoglobulins Integration of metabolism Koagulace a fibrinolysa Krebs cycle Mechanism of enzyme catalysis Metabolism of acylglycerols and sphingolipids Metabolism of amino acid Metabolism of erythrocytes Metabolism of heme Metabolism of iron Metabolism of nucleotides Metabolism of pentoses, glycogen, Fru and Gal Ribozymes Synthesis and degradation of fatty acids Synthesis of proteins Urea cycle Vitamins	Amino acid conversion Apoptosis Biochemical methods, proteins Evolution of proteins - the role of domain; Principles of proteomics Extracellular fluids Hormonal regulation of glycaemia Immunochemical methods Kinetics of enzyme reactions Macroergic bond does not exist Metabolism of leukocytes and platelets Plasma proteins Protein conformational disorders Proteins of extracellular matrix Regulation of carbohydrate metabolism Regulation of lipid metabolism	Alkaline phosphatase Hormonal regulation of glycaemia Protein assays Urine analyzes

2^nd year - summer semester

Materials:

Lectures	Seminars	Protocols for practical trainings
Biochemistry of acidobasic regulations Biochemistry of adipose tissue Biochemistry of blood Biochemistry of bone Biochemistry of cardiac muscle and lung Biochemistry of hormones derived from amino acids and proteins Biochemistry of liver Biochemistry of neurodegenerative diseases and prions Biochemistry of skin Biochemistry of thyroid hormones Cell signaling Complement Contractile proteins; molecular aspects of contractility Cytokine receptors and signal transduction Digestive enzymes Eicosanoids Free radicals Hormonal regulation and circadian rhytms Intracellular Ca signalling MAP kinases Mechanisms of vision Metabolisms of gut Minerals and trace elements Nutrice Stárnutí Steroid hormones	Abnormal composition of urine AMP-activated protein kinase (AMPK) Atherosclerosis FA receptors, lipid rafts Metabolic effects of CO2 Methods of immunodiffusion and precipitation in gels Monomeric G proteins Signal transmission at synapses	Chromogenic assay for the quantitative determination of antithrombin activity in plasma Immunoprecipitation techniques Ketosteroids The determination of AST and ALT activity in blood serum

LITERATURE:
Allan D. Marks, MD: Basic Medical Biochemistry a Clinical Approach, Lippincott Williams & Wilkins, 2009

R.K. Murray et al.: Harper's Illustrated Biochemistry, twenty-sixth edition, McGraw-Hill Companies, 2003

Color Atlas of Biochemistry

Biochemistry II

2nd year - winter semester

Materials:

2nd year - summer semester Materials:

2^nd year - winter semester

2^nd year - summer semester

Materials: