ESTIMATION OF INSULIN LEVELS IN
OBESE CHILDREN
Piotr Fichna, Boeda Skowronska. Eugeniusz Korman
Department of Pediatric Endocrynology and Diabetes Institute of
Pediatrics University of Medical Sciences, POZNAN, POLAND.
OBJECTIVE:
Pediatric obesity is a chronic and growing feeding problem in temporary world.
Recent statistical analyses in Poland show that the frequency of obesity in
children and adolescents is from 2,5% to 12% of the total childhood and
adolescents' population.The aim of the study was to determine the frequency of
hyperinsulinemia/insulin resistance in obese children.
METHODS: We
conducted in the patients oral glucose tolerance test (OGTT: 1.75g/kg body
weight, maximum 75g,) along with the estimation of glucose, insulin and
c-peptid levels at 0, 30, 60,90 and 120 minutes.
RESULTS; The
level of insulin after OGTT was estimated in 88 obese children (age range
5-19years, average age - 13,8 years) examined in our clinic for last two years.
The results of insulin levels were divided into 4 groups.
|
maximum insulin level (µlU/ml) |
Number of patients |
Age (years) |
BMI |
|||||||||||||||
|
|
boys |
girls |
both |
mean |
Sd |
mean |
|
|||||||||||
|
<100 |
18 |
12 |
30 |
12.7 |
3.99 |
28.4 |
|
|||||||||||
|
100-200 |
14 |
16 |
30 |
13.5 |
3.67 |
29.1 |
|
|||||||||||
|
200-300 |
7 |
8 |
15 |
14.2 |
3.35 |
33.0 |
|
|||||||||||
|
>300 |
7 |
6 |
13 |
14.6 |
1.71 |
32.7 |
|
|||||||||||
|
maximum insulin level(µlU/ml) |
insulin 0 |
insulin 120 |
IRI/Glycemia ratio |
|||||||||||||||
|
|
mean |
3d |
mean |
3d |
mean |
Sd |
|
|||||||||||
|
<100 |
17.7 |
10.03 |
55.4 |
21.16 |
0.21 |
0.12 |
|
|||||||||||
|
100-200 |
26.8 |
33.83 |
81.4 |
49.59 |
0.30 |
0.37 |
|
|||||||||||
|
200-300 |
21.1 |
5.60 |
160.2 |
82.40 |
0.22 |
0.06 |
|
|||||||||||
|
>300 |
45.0 |
22.40 |
201.7 |
113.81 |
0.50 |
0.27 |
|
|||||||||||
We found positive correlation between insulin maximum levels and BMI.
No relationship between fasting insulin level and cholesterol level was found.
In 18 patients (20,4%) the fasting insulin level was over 30 µlU/ml. Their
insulin/glycemia ratio was mean 0.65 SD 0.41. There was positive correlation
between IRI: glycemia ratio and insulin 0 level in these group of patients. In
9 cases apart from obesity arterial hypertension was recognized.
CONCLUSION:
It is concluded that obese children who manifested hyperinsulinemia/insulin
resistance should be taken into consideration as future cases of X syndrom.
Other risk factors of the metabolic X syndrome should be carefully investigated
during further observation in these children.