ROLE OF IMMUNOSTIMULATION WITH RIBOMUNYL IN PREVENTION
OF RESPIRATORY INFECTIONS IN CHILDREN
Wronski W.,
Planeta-Malecka I., Suski S., Pasnik J., Lukamowicz J
Department of Paediatrics, Military Medical
University, Institute of Polish Mothers
Memorial Hospital, Lodz, Poland
OBJECTIVE:
Based on the literature and our own clinical observation, an increase in
respiratory infections that account of more than 50% of hospitalised has been
found. The purpose of the study was to evalutate the role of immunostimulation
with Ribomunyl in preventive measures against recurring respiratory infections
in children.
METHODS:
Research was conducted in 180 children with long-standing respiratory
infections,aged from 2 to 17 years. Among analysed children, in 40
nasopharynx,in 40 tonsils inflammation, in 60 bronchitis and 40 bronchial
asthma were diagnosed. A comparative group consisted of 30 healthy children.
Their immunological condition Was estimated based on a number of CD3 and CD19
lymphocytes and CD4 and CD8 Subpopulation, including the designation of a
CD4/CD8 and functions of granulocytes of E.coli Phagotosis by netrophils and
monocytes and behaviour of G.A,M,E immumoglobulins in blood serum. The research
was conducted before and after the therapy complection and clinical observation
was performed for 12 months from completing the therapy with Ribomunyl. The
evaluation included the frequency and accuteness and selected parameters of
lungs ventilation (PEF). The drug was used according to the manufacturers
indications.
RESULTS: As
a result of conducted research identified in cellular related to a decreased,
of CD3 lymphocytes and a CD4/CD8 index as well as reduced phagocytosis activity
of neutrophils and monocytes were a reason of recurrend respiratory infections
in analysed children. Due to the immunostimulation treatment with Ribomunyl a
substantial improvement of selected parameters of cellular immunity. A
substantial Increase in the percentage of CD3 and CD4 subpopulation of
lymphocytes and normalisation of a CD4/CD8 index were obtained. In addition, an
increasd number of CD19 lymphpeytes was also identified. Children treated with
Ribomunyl indicated improvement in the range of a phagocytosis
system:percentage of neutrophils and monocytes, phagocytosis activity against
E.coli. In terms of humoral immunity a slight increase in serous IgG, IgA, IgM
was identified. In atpopic children a decrease of total IgE in blood serum was
observed. The enhancement of selected immunological parameters was accompanied
by a reducted number and acuteness of infections within 12 months of clinical observation. The use
of antibiotics and steroids was also reduced in this period. In analysed
children an increased PEF index was also observed in obturational infections of
bronchit and bronchial asthma.
CONCLUSIONS: l/.In children with long-standing
respiratory infections immunological disorders were identified in the field of
cellular immunology, which appears to be the main reason for recurrence.
2/.Upon immunostimulation treatment with Ribomunyl a substantial improvemet of
selected parameters of cellular immunity and also reduced frequency and
acuteness of infections occuring over a year was obtained. 3/.The treatment
with Ribomunyl efficiently equqlises immunological shortages.